RNA/DNA Recovery Vessel
Background
Clinical diagnostics and forensic sciences are two fields where the detection of nucleic acids (DNA, RNA) has become an important method. Nucleic acids are often obtained from swabs carrying liquid from patient or crime scene samples, these samples are sent to laboratories for analysis. The genetic sample must first be extracted from the swab; this process involves the addition of solutions and centrifugation steps to free the DNA/RNA from the swab.
Problem - the loss of valuable DNA or RNA sample
During the extraction process a proportion of the genetic sample is lost during the various stages which involve multiple micro-centrifuge tubes and the inherent absorbent qualities of the swab used. This reduces the amount of biological material available for analysis; a low yield during swab extraction can reduce the amount of nucleic acids below the detection limits of even the most sensitive methods, resulting in the loss of a potentially valuable sample.
Solution
Scientists from a London hospital have developed a device, that significantly increases the yield of DNA and RNA obtained during sample extraction from swabs.
How the DNA Recovery Vessel works
The fluid absorbing element of a swab (yellow) which holds a sample containing DNA/RNA, is submerged in lysis buffer fluid (left picture). The swab is put into the vessel which is closed by a lid and inverted. The fluid absorbing element is now pointing upwards. The vessel is centrifuged and the fluid is recovered from the fluid absorbing element (right picture).
Market Potential for Forensic Sciences
The current market for forensic DNA testing in the United States is estimated at $130 million, which includes $110 million per year from federal funding and $20 million from state funding. There are 351 publicly owned crime labs in the United States that account for an estimated 74% of the market1.
Market Potential for Healthcare
The U.S. market for DNA-based infectious disease tests is today a $1.1 billion industry2.
This product is currently available to license from NHSIL.
References:
1 Laboratory Industry Report: Forensic DNA Testing
2 Research and Markets: US DNA-Based Diagnostic Test and Equipment Market Analysis & Directions
